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From98US$ /night
Check-in
19Dec2025Select date
Check-out
20Dec2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

120 S Interstate Drive, Sikeston, Missouri, United States, 63801-8641
-
Near the Sikeston Depot Museum & Gallery
Very good
7.5
8.1
/10
3.8
3.7
/5

Best Western Plus Sikeston - A Business and Leisure Hotel with Indoor Pool, Fitness Center, and 24-Hour Business Facilities

Located near Interstates 55 and 57 and Highway 62, this 3-star Sikeston hotel features 55 air-conditioned rooms equipped with microwaves, MP3 docking stations, and laptop-friendly workspaces. Best Western Plus Sikeston provides both an indoor pool and a fitness center for active guests. Each accommodation includes a flat-screen TV with cable channels, a seating area, and a private bathroom with complimentary toiletries. The property maintains a 24-hour front desk, complimentary wired and wireless internet access, and a 24-hour business center with express check-out services. A grocery/convenience store serves on-site shopping needs, while a dining area offers refrigeration and coffee-making facilities. The hotel stands 28 miles from Cape Girardeau Regional airport, with Lambert's Café situated minutes away. Best Western Plus positions guests 2.5 miles from Malco Sikeston Cinema and Grill and 3.5 miles from Sikeston Depot Museum & Gallery.

Pros

Complete business infrastructure with 24-hour services and express check-out

On-site grocery store and dining facilities

Located at the intersection of three major highways

Close proximity to local entertainment venues and museums

Cons

28 miles from the nearest airport

Limited dining options within the hotel

“For families and those on driving holidays, this stop promises welcome convenience. The perks seem thoughtfully chosen: an indoor pool for year-round fun, a 24-hour business center, and even a small on-site store. I think the complimentary breakfast, often a make-or-break for travelers, seals the deal here.”
Hotel logo
Isabella MooreSenior Editorial Director at Petfriendlyhotels
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Select your room type

Cozy rooms, spacious suites, and family-friendly homes, all with flexible cancellation policies & special deals
King Room Sofa Bed Non-Smoking
2 persons
30 m² 
1 King-size bed and 1 Sofa bed
Shower
Coffee machine
Queen Room Two Queen Beds Non Smoking
2 persons
22 m² 
2 King Size Beds
Shower
Coffee machine
King Room Roll Shower Disability Access Non smoking
2 persons
22 m² 
1 King-size bed
Shower
Coffee machine
Queen Room Two Queen Beds Disability Access Non Smoking
2 persons
22 m² 
2 King Size Beds
Shower
Coffee machine
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Price and room availability calendar

Check availability and rates for your selected dates!

Facilities

Enjoy premium amenities for a relaxing stay with your pet

General

  • No smoking on site
  • Free Wi-Fi
  • Free parking
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Security
  • Lift
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Golf course

Guest Parking

  • Dryer

Services

  • Housekeeping
  • Laundry
  • Shops/Commercial services

Business

  • Business centre
  • Fax/Photocopying

Children

  • Children's buffet

Spa & Leisure

  • Indoor swimming pool
  • Sun loungers
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Washing machine
  • Free toiletries

Self-catering

  • Dryer

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

120 S Interstate Drive, Sikeston, Missouri, United States, 63801-8641
Map view
120 S Interstate Drive, Sikeston, Missouri, United States, 63801-8641
Restaurants
McDonald's
920 m
2605 E Malone
Explore Sikeston
Local Experiences Near Best Western Plus Sikeston
Top Attractions
Activities
Dining
Entertainment
Sikeston Depot Museum & Gallery
15 minutes' drive
Historic museum showcasing Sikeston's history, with various local exhibits and stunning galleries.
Malco Sikeston Cinema and Grill
10 minutes' drive
Watch the latest films at this cinema with a dining experience, offering comfortable seating and meal options.
Sikeston Sports Complex
15 minutes' drive
A vibrant sports complex featuring fields for various sports, perfect for family outings and local tournaments.
Kingdom Hall of Jehovah's Witnesses
10 minutes' drive
Community center for gatherings and events, offering a glimpse into the local culture and worship activities.
Boot Heel Golf Club
10 minutes' drive
18-hole golf course set in scenic surroundings, perfect for golf enthusiasts and casual players alike.
Sikeston Sports Complex
15 minutes' drive
Sports fields for soccer, baseball, and more, ideal for family fun, tournaments, and active gatherings.
McDonald's
12 minutes' walk
Familiar fast food with burgers, fries, and breakfast items, perfect for a quick bite any time of day.
Rick's Place
10 minutes' drive
Casual dining atmosphere serving American classics; known for their steaks and warm hospitality.
Malco Sikeston Cinema and Grill
10 minutes' drive
Catch movies with in-theater dining; known for special screenings and comfy seating for a great night out.
Local Bars
10 minutes' drive
Various local bars featuring live music, karaoke nights, and vibrant atmospheres for all ages.
Getting around
City Centre
Sikeston9 min  ·  5.4 km
Airports
Cape Girardeau Regional Airport (CGI)65 min  ·  43.0 km
Barkley Regional Airport (PAH)131 min  ·  87.3 km
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 11 am
Guest Parking
Private parking is possible on site for free.
Internet
is available in for free.
Breakfast
All visitors are offered a american breakfast for a fee. 
Pets
Pets are allowed on request.
Number of rooms:
55
Former name
Holiday Inn Express
FAQs
About Best Western Plus Sikeston
What is the distance between Best Western Plus Sikeston and Cape Girardeau Regional Airport?
The hotel is 43 km from Cape Girardeau Regional Airport.
What are the check-in and check-out times at Best Western Plus Sikeston?
Check-in is at 15:00 and check-out is at 11:00.
What amenities does Best Western Plus Sikeston offer for fitness enthusiasts?
The hotel features a fitness center and an indoor swimming pool available year-round.
Is parking available at Best Western Plus Sikeston?
The hotel offers free private parking on-site without the need for reservation.
Are there dining options available at Best Western Plus Sikeston?
A buffet, à la carte, or continental breakfast is served at the property.
What nearby attractions can guests visit from Best Western Plus Sikeston?
Nearby attractions include Lambert's Café (3 km) and the Sikeston Depot Museum & Gallery (6 km).
What room amenities are provided in the accommodations at Best Western Plus Sikeston?
Rooms include air conditioning, a flat-screen TV, a refrigerator, a coffee machine, and free toiletries.
Does Best Western Plus Sikeston have a business center?
The hotel offers a 24-hour business center to cater to the needs of traveling professionals.
What leisure activities are available at Best Western Plus Sikeston?
Guests can enjoy access to an indoor pool and a golf course located on-site.

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