Save
up to 10%
when booking directly with us!
Check rooms and rates
From332US$ /night
Check-in
19Mar2026Select date
Check-out
20Mar2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
-
Near Shipwreck Island Water Park
Great
8.8
/10

Hilton Jacksonville At Mayo Clinic - A Modern Hotel with Streaming-Equipped Rooms and Garden Terrace

Located 18 miles from Union, this Jacksonville hotel features rooms and suites equipped with modern amenities. Hilton Jacksonville At Mayo Clinic offers accommodations ranging from double rooms to quadruple rooms and suites, each featuring flat-screen TVs with streaming services. All units come with air conditioning, tea and coffee makers, wardrobes, and safe deposit boxes. Private bathrooms include showers, with select suites offering additional bath facilities and free toiletries. The property includes an outdoor terrace with garden furniture. The Hilton's location provides access to several attractions, including Adventure Landing Jacksonville Beach and Paws Park within 2.5 miles, Mind Bender Escape Rooms at 2.5 miles, and Jacksonville Beach Pier at 3.5 miles. Castaway Island Preserve stands 2.5 miles from the property.

Pros

Garden terrace with outdoor furniture for guest relaxation

Quadruple rooms available for larger groups or families

Located within 3.5 miles of multiple beach attractions and entertainment venues

Cons

18 miles distance from Union

Limited on-site dining options

View all

Select your room type

Cozy rooms, spacious suites, and family-friendly homes, all with flexible cancellation policies & special deals
Queen Room Two Queen Beds Water View Hearing Accessible
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Water View
2 persons
345 sq. feet 
2 King Size Beds
Shower
Heating
Queen Room Two Queen Beds Hearing Access
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Queen Room Two Queen Beds
2 persons
345 sq. feet 
2 King Size Beds
Shower
Coffee machine
Click button to see more rooms
Show all rooms
Show all roomsLess

Price and room availability calendar

Check availability and rates for your selected dates!

Facilities

Enjoy premium amenities for a relaxing stay with your pet

General

  • No smoking on site
  • Wi-Fi
  • Free parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • No pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Lift
  • ATM/Cash machine
  • Fireplace
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre

Services

  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Shops/Commercial services
  • Welcome drink

Dining

  • In-room breakfast
  • Restaurant
  • Bar/ Lounge area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Outdoor swimming pool
  • Beach umbrellas
  • Sun loungers
  • Sun terrace
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries
  • Sink

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Curtains
Show more

Hilton Jacksonville At Mayo Clinic Location

4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Map view
4745 Transformation Way, Jacksonville, Florida, United States, FL 32224
Explore Jacksonville
Local Experiences
Top Attractions
Activities
Dining
Entertainment
Saint Ephrem Syriac Catholic Church
20 minutes' walk
An architectural gem with stunning stained glass. Visitors appreciate its serene atmosphere and reflection spaces.
Windsor Parke Golf Club
5-minute drive
A beautiful 18-hole course featuring lush landscapes. Great for family outings and golf enthusiasts.
Castaway Island Preserve
Castaway Island Preserve
40 minutes' drive
This natural area offers trails and scenic views ideal for birdwatching and enjoying the outdoors.
Urban Golf
10-minute drive
An indoor golf experience perfect for all skill levels. Offers lessons and equipment rentals.
Adventure Landing Jacksonville Beach
Adventure Landing Jacksonville Beach
10-minute drive
A themed amusement park featuring arcade games, mini-golf, and thrilling water attractions for families.
The Capital Grille
10 minutes' drive
Upscale steakhouse with an elegant atmosphere. Known for dry-aged steaks and an extensive wine list.
Bonefish Grill
5-minute drive
Relaxed dining with a focus on fresh seafood. Signature Bang Bang Shrimp is a must-try.
Regal Cinema
10-minute drive
Modern theater featuring the latest films, comfortable seating, and a family-friendly atmosphere.
Comedy Zone
15-minute drive
A venue for live comedy shows. Offers a fun night out with featuring local and national comedians.
Getting around
City Centre
Jacksonville33 min  ·  13.6 mi
Airports
Jacksonville International Airport (JAX)67 min  ·  27.5 mi
St. Augustine, FL (UST)71 min  ·  29.0 mi
Train
Jacksonville Electric Authority Southside Generating Station Wharf29 min  ·  11.8 mi
Union Station35 min  ·  14.4 mi
Looking for exclusive early booking discounts?
Unlock special rates for your next adventure with your pet today!
Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Internet
Wireless internet is available in for free.
Pets
Pets are not allowed.
Number of rooms:
252

Reviews and Ratings

Feedback about Hilton Jacksonville At Mayo Clinic from previous guests about their experience.
Review score
Based on 9 verified reviews
8.6/10
Great
82%
Recommend
Pros
Comfortable beds
Clean rooms
Friendly staff
Good breakfast
Cons
Limited parking
Small pool
Elevator issues
Guest reviews
based on 57 reviews
8.8/10
No reviews yet on our siteUnfortunately, our guests have not yet left any reviews for this hotel, but you can read reviews from Booking.com.
Open reviews
FAQs
About Hilton Jacksonville At Mayo Clinic
What is the check-in and check-out time at Hilton Jacksonville At Mayo Clinic?
Check-in is at 16:00 and check-out is by 11:00.
How far is Hilton Jacksonville At Mayo Clinic from Jacksonville International Airport?
The hotel is located 42 km from Jacksonville International Airport.
What are some nearby attractions to Hilton Jacksonville At Mayo Clinic?
Nearby attractions include Jacksonville Beach Golf Club (8 km) and Kathryn Abbey Hanna Park (17 km).
Is there parking available at Hilton Jacksonville At Mayo Clinic?
Public parking is available on-site for free.
What dining options are available at Hilton Jacksonville At Mayo Clinic?
The hotel features an on-site restaurant offering full English/Irish and American breakfasts.
What amenities can guests expect in the rooms at Hilton Jacksonville At Mayo Clinic?
Rooms include air conditioning, a flat-screen TV, a desk, a safety deposit box, and tea/coffee making facilities.
Does Hilton Jacksonville At Mayo Clinic have a fitness center?
Yes, there is a fitness center available for guest workouts.
What features are included in the general facilities at Hilton Jacksonville At Mayo Clinic?
Facilities include an outdoor swimming pool, a shared lounge, a terrace, and a business center.
Is Wi-Fi available at Hilton Jacksonville At Mayo Clinic?
Free Wi-Fi is available throughout the hotel.

Next best alternative

Consider them for your next trip.
Check-in
19Mar2026Select date
Check-out
20Mar2026Select date
Rooms and Guests2 Guests, 1 Room