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From203US$ /night
Check-in
31Dec2025Select date
Check-out
01Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
-
Close to Mayo Clinic
Great
8.9
9.3
/10
4.6
4.5
/5

Residence Inn By Marriott Jacksonville-Mayo Clinic Area - All-suite hotel with kitchen-equipped rooms, outdoor pool, and complimentary medical shuttle service

Located less than a mile from Mayo Clinic Florida, this 3-star Jacksonville hotel features 155 air-conditioned suites with fully equipped kitchens and 50-55" Smart HDTVs with Netflix. Each suite at Residence Inn includes a living area, dining space, and a private bathroom with a bath, hairdryer, and complimentary toiletries. The property operates a complimentary hourly shuttle service to Mayo Clinic from 7 AM to 5 PM and offers post-treatment nursing care partnerships. Guests have access to a 2678-square-foot conference space, 24-hour business center, and property-wide free WiFi. The outdoor swimming pool and 24-hour fitness center provide recreational options. Dining options include a daily buffet or American breakfast, a lobby bar serving beverages and light meals, and an on-site grocery store. The hotel sits 9 minutes from St. Johns Town Center and 21.5 miles from the nearest airport.

Pros

Specialized medical guest lounge in the Claudette O'Brien Gerhold Gallery

Partnership with American In-Home Care for personalized nursing services

Individual suite air cooling and dehumidifying system

Complimentary long-term parking available

Cons

26.5 miles distance from Northeast Florida Regional Airport

Pet weight limit restricted to 50 pounds

“This hotel stands out for its commitment to guests connected with the Mayo Clinic, creating a supportive environment with practical amenities like in-suite kitchens and a shuttle service. I was especially struck by the reports of staff empathy and personalized care, which seem to go beyond standard hospitality. Its location provides quiet convenience near the clinic, with added perks like complimentary breakfast and pet-friendly policies enhancing its appeal for longer stays.”
Hotel logo
Isabella MooreSenior Editorial Director at Petfriendlyhotels
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Select your room type

Cozy rooms, spacious suites, and family-friendly homes, all with flexible cancellation policies & special deals
One-Bedroom Queen Suite Hearing Accessible
2 persons
52 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
King Studio Suite Sofa Bed Adapted Tub Mobility Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
Queen Corner Suite
2 persons
60 m² 
1 King-size bed and 1 Sofa bed
Shower
Coffee machine
King Studio Suite Sofa Bed Hearing Accessible
2 persons
38 m² 
1 King-size bed and 1 Sofa bed
Coffee machine
Heating
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Facilities

Enjoy premium amenities for a relaxing stay with your pet

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Lift
  • Fireplace
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Golf course

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Free shuttle service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Grocery shopping service
  • Shops/Commercial services

Dining

  • Bar/ Lounge area
  • Picnic area/ Tables

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots
  • Children's buffet
  • Board games

Facilities for people with disabilities

  • Toilet for disabled
  • Bathroom for disabled

Spa & Leisure

  • Heated swimming pool
  • Outdoor swimming pool
  • Sun loungers
  • BBQ facilities
  • Leisure/ TV room

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Dining table

Bathroom

  • Free toiletries
  • Sink

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Carpeted floor
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Location

4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Map view
4905 San Pablo Road South, Jacksonville, Florida, United States, 32224
Nearby
Hospital
Mayo Clinic Jacksonville
1.0 km
Restaurants
Bundy Cafe & Atrium
910 m
4500 San Pablo Rd S Mayo Clinic
Explore Jacksonville
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Mayo Clinic Jacksonville
Mayo Clinic Jacksonville
12 minutes' walk
World-renowned medical facility with stunning architecture and gardens; perfect for health-focused events.
Harbor City Municipal Golf Course
Harbor City Municipal Golf Course
5 minutes' drive
Challenging 18-hole course surrounded by lush landscapes, ideal for golfers looking for a fun day.
Shipwreck Island Water Park
10 minutes' drive
A vibrant water park featuring thrilling slides and family-friendly pools for a perfect summer day.
Cradle Creek Preserve
Cradle Creek Preserve
40 minutes' drive
Scenic trails for hiking and nature watching, offering tranquility and chances to spot local wildlife.
Urban Golf
10 minutes' drive
Indoor golfing experience with simulators; ideal for both casual players and golf enthusiasts.
Bundy Cafe & Atrium
Bundy Cafe & Atrium
10 minutes' walk
Charming café known for its fresh, locally-sourced breakfast and lunch options in a cozy setting.
Ocean 60
10 minutes' drive
Elegant seafood restaurant with ocean views, famous for its signature dishes and refined decor.
Regal Beach Boulevard 18
Regal Beach Boulevard 18
10 minutes' drive
Multiplex theater offering the latest films and comfy seating, perfect for a relaxing evening out.
Mind Bender Escape Rooms
Mind Bender Escape Rooms
10 minutes' drive
Exciting escape rooms with themed puzzles; great for friends and family seeking fun challenges.
Getting around
City Centre
Jacksonville35 min  ·  22.7 km
Airports
Jacksonville International Airport (JAX)67 min  ·  44.6 km
St. Augustine, FL (UST)71 min  ·  47.0 km
Train
Jacksonville Electric Authority Southside Generating Station Wharf30 min  ·  19.8 km
Union Station36 min  ·  24.0 km
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Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
Public parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Pets
Pets are allowed on request.
Number of floors:
7
Number of rooms:
181
Former name
residence inn by marriott jacksonville - mayo clinic area
FAQs
About Residence Inn By Marriott Jacksonville-Mayo Clinic Area
What are the check-in and check-out times at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Check-in is at 16:00 and check-out is by 11:00.
How far is Residence Inn By Marriott Jacksonville-Mayo Clinic Area from Jacksonville International Airport?
The hotel is 43 km from Jacksonville International Airport.
Is parking available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Public parking is available on-site free of charge and does not require a reservation.
What amenities are included in the rooms at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Rooms are equipped with air conditioning, a flat-screen TV with satellite channels, a kitchen, and a private bathroom.
What food options does Residence Inn By Marriott Jacksonville-Mayo Clinic Area offer?
Guests can enjoy a buffet or American breakfast, and the hotel features a bar with food service.
What recreational facilities are available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel offers an outdoor swimming pool and a 24-hour fitness center.
What business facilities does Residence Inn By Marriott Jacksonville-Mayo Clinic Area provide?
The hotel features a 24-hour business center and meeting spaces for business needs.
How close is Residence Inn By Marriott Jacksonville-Mayo Clinic Area to Mayo Clinic Florida?
The hotel is a 2-minute drive and approximately 1 km from Mayo Clinic Florida.
Is there a shuttle service available at Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
The hotel offers a complimentary hourly shuttle service from 7:00 to 17:00.
What are some nearby attractions to Residence Inn By Marriott Jacksonville-Mayo Clinic Area?
Nearby attractions include St Johns Town Center (approximately 9 minutes away) and Jacksonville Beach Golf Club (8 km away).

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Check-in
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Check-out
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