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From166US$ /night
Check-in
31Dec2025Select date
Check-out
01Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
-
Close to Falls Park
Great
8.6
9.3
/10
4.5
/5

Home2 Suites By Hilton Sioux Falls Sanford Medical Center - All-suite hotel with indoor pool, connected to medical center via skywalk

Located in the center of Sioux Falls and connected to Sanford Medical Center via climate-controlled skywalk, this 3-star Sioux Falls hotel features 80 suites with full kitchens, 42-inch LCD TVs, and free WiFi. Home2 Suites By Hilton Sioux Falls Sanford Medical Center provides a free hot breakfast buffet, an indoor saline swimming pool, and a whirlpool. The property includes 950 square feet of event facilities, a 24-hour fitness center, and a business center with express check-out services. Each suite contains a dishwasher, refrigerator, microwave, and a work desk. The unique Spin2Cycle facility combines laundry and fitness equipment. The University of Sioux Falls stands 5 minutes away on foot, while Augustana College is within a half-mile distance. Falls Park and the Denny Sanford Premier Center are both accessible within 6 minutes by car.

Pros

Direct access to Sanford Medical Center through climate-controlled skywalk

Free grocery delivery service available to all suites

Combined laundry and fitness facility for multitasking

Pet-friendly accommodations (maximum 2 pets)

Cons

Full room cleaning service only available every fourth night

Located 6 miles from Sioux Falls Regional Airport

“Home2 Suites' proximity to Sanford Medical Center, even via skywalk, is a clear advantage for many guests. The all-suite setup, complete with in-room kitchens, supports longer stays and flexible schedules, but I noted some noise issues reported by guests. I think the laundry-fitness combo is a smart, time-saving touch.”
Hotel logo
Isabella MooreSenior Editorial Director at Petfriendlyhotels
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Select your room type

Cozy rooms, spacious suites, and family-friendly homes, all with flexible cancellation policies & special deals
King Studio Suite Non-Smoking
2 persons
40 m² 
1 King-size bed
Heating
Air conditioning
Queen Studio Two Queen Beds Non-Smoking
2 persons
40 m² 
2 King Size Beds
Heating
Air conditioning
King Studio Suite Hearing Access or Non-Smoking
2 persons
40 m² 
1 King-size bed
Heating
Air conditioning
Queen Studio Two Queen Beds Mobility Access or Non-Smoking
2 persons
40 m² 
2 King Size Beds
Heating
Air conditioning
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Facilities

Enjoy premium amenities for a relaxing stay with your pet

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • 24-hour reception
  • Express check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Luggage storage
  • Lift

Sports & Fitness

  • Fitness centre

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Laundry

Business

  • Business centre
  • Fax/Photocopying

Spa & Leisure

  • Indoor swimming pool
  • Jacuzzi

Room features

  • Air conditioning
  • Heating
  • Sitting area
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV
  • AM/FM alarm clock

Room decor

  • Curtains
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Location

1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
Map view
1120 S Grange Avenue, Sioux Falls, South Dakota, United States, 57105
Nearby
1305 W 18th St In the Sanford USD Medical Center
Sioux Empire Medical Museum
290 m
1001 SW Avenue
Sioux Falls Stadium
530 m
Restaurants
The Co-op of Sioux Falls
860 m
410 W 18th St
Azteca
1.1 km
811 S Minnesota Ave
Toppers Pizza
1.1 km
817 S Minnesota Ave
Taco John's
1.0 km
1100 S Minnesota Ave
Papa John's Pizza
1.1 km
711 S Minnesota Ave
Abelardo's Mexican Food
1.1 km
1200 S Minnesota Ave
Pho Quynh
960 m
1100 W 12th St
Explore Sioux Falls
Local Highlights
Top Attractions
Activities
Dining
Entertainment
Sioux Empire Medical Museum
4 minutes' walk
Historical exhibits related to medical practices in the area, showcasing Sioux Falls' health care evolution.
Michelangelo's David replica
15 minutes' walk
A detailed replica of Michelangelo's masterpiece, located in the heart of downtown, a unique cultural point.
Great Plains Zoo & Delbridge Museum of Natural History
25 minutes' walk
Home to over 900 animals and diverse exhibits, this zoo is perfect for family outings and wildlife enthusiasts.
Pettigrew Home and Museum
20 minutes' walk
A historical site featuring artifacts and art from Sioux Falls' early days, ideal for history buffs and families.
Sioux Falls Bike Trail
25 minutes' walk
Scenic biking and walking trails encompass the beauty of Sioux Falls, popular for outdoor enthusiasts.
Midco Aquatic Center
16 minutes' walk
Family-friendly water park featuring slides, pools, and relaxation areas, suitable for a fun day of swimming.
Tuthill Park
30 minutes' walk
Expansive park with trails and a beautiful view, perfect for picnics and casual strolls, offering serene relaxation.
The Co-op of Sioux Falls
11 minutes' walk
A casual spot serving local specialties and fresh ingredients, ideal for health-conscious diners.
Azteca
13 minutes' walk
Vibrant eatery offering authentic Mexican cuisine with a lively atmosphere; great for family dinners.
Lucky Lady Casino
15 minutes' walk
A fun dining spot that pairs classic American dishes with gaming experiences for an entertaining night out.
Downtown Sioux Falls
20 minutes' walk
A hub of nightlife featuring bars, restaurants, and events, perfect for an evening out with friends or a date night.
Sioux Falls Stadium
7 minutes' walk
Home to local sports events, this venue provides excitement year-round with games and community events.
Getting around
City Centre
Sioux Falls10 min  ·  800 m
Airports
Sioux Falls Regional Airport (FSD)12 min  ·  7.9 km
Stronsay Airport (soy)130 min  ·  86.3 km
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Property information and rules
Check-in
from 15:00-23:59
Check-out
until 12 pm
Guest Parking
Public parking is possible on site for free.
Internet
is available in for free.
Breakfast
A buffet breakfast is served at affordable prices. 
Children & extra beds
There are no extra beds provided in a room.  There are no cots provided in a room. 
Pets
Pets are allowed on request.
Number of floors:
4
Number of rooms:
76
FAQs
About Home2 Suites By Hilton Sioux Falls Sanford Medical Center
What is the check-in and check-out policy at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Check-in is at 15:00 and check-out is at 12:00.
How far is Home2 Suites By Hilton Sioux Falls Sanford Medical Center from Sioux Falls Regional Airport?
The hotel is 5 km from Sioux Falls Regional Airport.
What recreational facilities are available at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Guests can enjoy an indoor saline swimming pool, hot tub, and a 24-hour fitness center.
What room amenities can guests expect at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Rooms feature air conditioning, a flat-screen TV, a kitchen with a refrigerator and microwave, and complimentary Wi-Fi.
What dining options are available at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
The hotel offers a free hot breakfast buffet and also has a business center for guests.
What is the nearest hospital to Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
The nearest hospital is Sanford Medical Center, located a short distance from the hotel.
Which restaurants are located close to Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Nearby restaurants include Toppers Pizza, Taco John's, Abelardo's Mexican Food, Domino's Pizza, and Pho Quynh, all within 1 km.
What business amenities does Home2 Suites By Hilton Sioux Falls Sanford Medical Center provide?
The hotel features a business center, meeting facilities, and express check-in/out services.
What unique features does Home2 Suites By Hilton Sioux Falls Sanford Medical Center offer for extended stays?
The hotel offers a Spin2Cycle facility combining laundry and fitness, in-room kitchen facilities, and a complimentary grocery delivery service.
Is parking available at Home2 Suites By Hilton Sioux Falls Sanford Medical Center?
Public parking is available on-site for free, and reservations are not needed.

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